Research findings show that pitavastatin suppresses skin and pancreatic cancers by inhibiting interleukin-33.

A recent study conducted by researchers at Mass General Cancer Center has found that statins, which are widely used to reduce cholesterol, might inhibit a specific pathway linked to cancer development caused by chronic inflammation. These results were reported in...... 

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“Chronic inflammation is a major cause of cancer worldwide,” said senior author Shawn Demehri, MD, PhD, a principal investigator at the Center for Cancer Immunology and Cutaneous Biology Research Center of Massachusetts General Hospital and an associate professor of Dermatology at Harvard Medical School. “We investigated the mechanism by which environmental toxins drive the initiation of cancer-prone chronic inflammation in the skin and pancreas,” says Demehri, who is also the Bob and Rita Davis Family MGH Research Scholar 2023-2028.

( ) “Furthermore, we examined safe and effective therapies to block this pathway in order to suppress chronic inflammation and its cancer aftermath.”

Research Methods and Findings

Demehri and his colleagues’ study relied on cell lines, animal models, human tissue samples, and epidemiological data. The group’s cell-based experiments demonstrated that environmental toxins (such as exposure to allergens and chemical irritants) activate two connected signaling pathways called the TLR3/4 and TBK1-IRF3 pathways. This activation leads to the production of the interleukin-33 (IL-33) protein, which stimulates inflammation in the skin and pancreas that can contribute to the development of cancer.

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When they screened a library of U.S. Food and Drug Administration–approved drugs, the researchers found that a statin, pitavastatin, effectively suppresses IL-33 expression by blocking the activation of the TBK1-IRF3 signaling pathway. In mice, pitavastatin suppressed environmentally-induced inflammation in the skin and the pancreas and prevented the development of inflammation-related pancreatic cancers.

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The Pentagon said Thursday that humanitarian aid will soon begin flowing onto the Gaza shore through the new pier that was anchored to the beach overnight and will begin reaching those in need almost immediately.

Sabrina Singh, Pentagon spokeswoman, told reporters the U.S. believes there will be no backups in the distribution of the aid, which is being coordinated by the United Nations.

The U.N., however, said fuel imports have all but stopped and this will make it extremely difficult to deliver the aid to Gaza’s people, all 2.3 million of whom are in acute need of food and other supplies after seven months of intense fighting between Israel and Hamas.

“We desperately need fuel,” U.N. deputy spokesman Farhan Haq said. “It doesn’t matter how the aid comes, whether it’s by sea or whether by land, without fuel, aid won’t get to the people.”